RAD-140 powder (Testolone)

Introduction

RAD-140 powder (testolone) is the nonsteroidal selective androgen receptor modulator 2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile. It was developed by Radius Health and is also coded vosilasarm and EP0062. The scaffold is a chlorobenzonitrile linked to a cyanophenyl-oxadiazole, with a free secondary alcohol. It is not a steroid and it is not the benzoate ester RAD-150.

Published binding data give an androgen-receptor Ki of about 7 nM, with selectivity over progesterone, estrogen, and glucocorticoid receptors in the reported panel. A first-in-human phase 1 study in postmenopausal women with ER-positive, HER2-negative metastatic breast cancer has been published. It is not an approved medicine. Analytical suppliers list it as a forensic reference because it has been found in athlete samples and in seized performance-enhancing products. The powder is supplied for analytical and in vitro research only.

Key features and benefits – Buy RAD-140 Powder (Testolone)

• Defined oxadiazole SARM. The chlorobenzonitrile, cyanophenyl-oxadiazole, and free alcohol distinguish it from arylpropionamide SARMs and from RAD-150.
• Parent of the ester. RAD-150 is the benzoate, about 497.9 g·mol−1. RAD-140 is the alcohol, 393.8 g·mol−1. They must be assayed separately.
• Documented identity. CAS 1182367-47-0, PubChem CID 44200882, formula C20H16ClN5O2.
• Weighable crystalline solid. Suitable for reference standards and stock solutions when the COA confirms purity and isomer.
• Laboratory-only handling. Intended for controlled chemical and in vitro work, not for dietary or performance use.

Specifications Of Buy RAD-140 Powder (Testolone)

Applications in research

Appropriate uses are non-clinical and institutionally approved:

• Analytical reference material for HPLC, LC-MS, and NMR identification of RAD-140 in raw material or spiked samples.
• Comparison with RAD-150, including hydrolysis studies that use the alcohol as the reference parent.
• Androgen-receptor binding or reporter assays where the protocol covers this compound.
• Forensic screening of products labeled as testolone or RAD-140.
• Impurity and stereoisomer profiling.

Do not describe or imply oral use, stacking, or any human performance protocol. Oncology trial doses are not a use instruction.

Purity and testing

A defensible product claim rests on the batch certificate, not on a generic percentage.

• HPLC for chromatographic purity against a stated method, with a check that the main peak is the alcohol and not the benzoate.
• 1H NMR for the oxadiazole-linked rings, the methyl groups, and the free alcohol. Benzoate aromatics indicate RAD-150.
• Mass spectrometry for the molecular ion consistent with C20H16ClN5O2, including the chlorine isotope pair.
• Stereochemical check if the supplier claims the (1R,2S) isomer.
• Residual solvent if the supplier states it.

Store the COA with the lot number. Do not label this powder with the RAD-150 CAS.

Disclaimer

For laboratory research use only. Not for human or veterinary consumption, not for diagnostic or therapeutic use, and not a food, drug, or dietary supplement. RAD-140 is not an authorized medicine. SARMs are prohibited by the World Anti-Doping Agency at all times. Health authorities have warned of possible cardiovascular and liver risks from SARM-containing bodybuilding products. The published phase 1 cancer study reported elevations in AST, ALT, and bilirubin. Legal status varies. Buyers are responsible for confirming legality, licensing, import rules, and institutional approval before ordering or handling. Handle with standard laboratory PPE and dispose of waste under local hazardous-chemical rules. No statement on this page is a claim of safety, efficacy, or fitness for any human application.

Frequently asked questions

What is RAD-140?
RAD-140, also called testolone and vosilasarm, is a nonsteroidal SARM. It is a chlorobenzonitrile–oxadiazole with a free alcohol, formula C20H16ClN5O2.

Is this the same as RAD-150?
No. RAD-150 is the benzoate ester, CAS 1208070-53-4, about 497.9 g·mol−1. RAD-140 is the parent alcohol, CAS 1182367-47-0, formula weight 393.8. One milligram of one is not one milligram of the other.

Which CAS number applies?
CAS 1182367-47-0. Confirm the (1R,2S) configuration on the COA, not only the CAS.

What purity is supplied?
Only the figure on the lot COA. A page-level claim such as ≥98% by HPLC should match the method used for that batch and should distinguish the alcohol from RAD-150.

How should it be stored?
Sealed, cool, dry, and protected from light, commonly at −20 °C for reference material. Record the lot number with the COA.

Can it be used in humans?
No. It is not an approved drug or supplement and is not sold for consumption. Anti-doping rules prohibit SARMs. Check local law before purchase.

What analytical methods confirm identity?
HPLC purity, NMR for the oxadiazole and free alcohol, and mass spectrometry consistent with C20H16ClN5O2, including the chlorine isotope pair. Absence of a benzoate signal separates it from RAD-150.