LGD-4033 Powder (Ligandrol)

Introduction

LGD-4033 powder (ligandrol) is a nonsteroidal selective androgen receptor modulator developed under the code VK-5211. The assigned structure is 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile, a pyrrolidine with two trifluoromethyl groups and a benzonitrile. It is not a steroid and is distinct from YK-11.

Published work describes high androgen-receptor affinity, on the order of 1 nM, with selectivity for muscle and bone over prostate in animal models. It has been studied clinically for muscle wasting, including after hip fracture, but it is not an approved medicine. Analytical suppliers list it as a forensic reference because it has been found in athlete urine and in seized performance-enhancing products. The powder is supplied for analytical and in vitro research only.

Key features and benefits – Buy LGD-4033 Powder (Ligandrol)

• Nonsteroidal SARM scaffold. The pyrrolidine, trifluoroethanol, and trifluoromethyl-benzonitrile distinguish it from steroidal SARMs such as YK-11 and from testosterone.
• Defined stereochemistry. The (2R,1R) configuration is part of the identity. A racemate or the wrong diastereomer is a different material.
• Documented identity. CAS 1165910-22-4, formula C14H12F6N2O, formula weight 338.3.
• Weighable crystalline solid. Suitable for reference standards and stock solutions when the COA confirms purity.
• Laboratory-only handling. Intended for controlled chemical and in vitro work, not for dietary or performance use.

Specifications Of Buy LGD-4033 Powder (Ligandrol)

Applications in research

Appropriate uses are non-clinical and institutionally approved:

• Analytical reference material for HPLC, LC-MS, and NMR identification of ligandrol in raw material or spiked samples.
• Androgen-receptor binding or reporter assays, with comparison to DHT or other SARMs.
• Forensic screening of products labeled as ligandrol or LGD-4033.
• Impurity and stereoisomer profiling.
• Method development for anti-doping and urine analysis.

Do not describe or imply oral use, stacking, or any human performance protocol.

Purity and testing

A defensible product claim rests on the batch certificate, not on a generic percentage.

• HPLC for chromatographic purity against a stated method.
• 1H NMR and 19F NMR for the pyrrolidine, the trifluoroethanol, and the two CF3 groups.
• Mass spectrometry for the molecular ion consistent with C14H12F6N2O.
• Chiral or diastereomer check if the supplier claims the (2R,1R) isomer.
• Residual solvent and water if the supplier states them.

Store the COA with the lot number. Do not treat a racemic or unnamed isomer as ligandrol without that check.

Disclaimer

For laboratory research use only. Not for human or veterinary consumption, not for diagnostic or therapeutic use, and not a food, drug, or dietary supplement. LGD-4033 is not an authorized medicine. SARMs are prohibited by the World Anti-Doping Agency at all times. Health authorities have warned of possible cardiovascular and liver risks from SARM-containing bodybuilding products. Legal status varies. Buyers are responsible for confirming legality, licensing, import rules, and institutional approval before ordering or handling. Handle with standard laboratory PPE and dispose of waste under local hazardous-chemical rules. No statement on this page is a claim of safety, efficacy, or fitness for any human application.

Frequently asked questions

What is LGD-4033?
LGD-4033, also called ligandrol and VK-5211, is a nonsteroidal SARM. It is a pyrrolidinyl benzonitrile with two trifluoromethyl groups, formula C14H12F6N2O.

Is it the same as YK-11 or testosterone?
No. YK-11 is a steroidal SARM (C25H34O6). Testosterone is an endogenous androgen. LGD-4033 is a synthetic nonsteroidal ligand (CAS 1165910-22-4).

Which CAS number applies?
CAS 1165910-22-4. Confirm the stereochemistry on the COA, not only the CAS.

What purity is supplied?
Only the figure on the lot COA. A page-level claim such as ≥98% by HPLC should match the analytical method actually used for that batch.

How should it be stored?
Sealed, cool, dry, and protected from light, commonly at −20 °C. It is hygroscopic, so limit air and moisture exposure. Record the lot number with the COA.

Can it be used in humans?
No. It is not an approved drug or supplement and is not sold for consumption. Anti-doping rules prohibit SARMs. Check local law before purchase.

What analytical methods confirm identity?
HPLC purity, 1H and 19F NMR, and mass spectrometry consistent with C14H12F6N2O. A stereochemical check is needed if the (2R,1R) isomer is claimed.