GW-501516 Powder

Introduction

GW-501516 powder is 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid. It was invented in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline and is also coded GW1516 and GSK-516. Listing names include cardarine and endurobol. It is a selective agonist of peroxisome proliferator-activated receptor delta (PPARδ), not an androgen-receptor ligand and not a steroid.

Published binding data give a Ki of about 1 nM and an EC50 of about 1 nM at PPARδ, with greater than 1,000-fold selectivity over PPARα and PPARγ in the reported assays. Clinical development for metabolic disease was stopped. Long-term animal studies found tumors in multiple organs. It is not an approved medicine. The World Anti-Doping Agency prohibits it as a metabolic modulator. The powder is supplied for analytical and in vitro research only.

Key features and benefits – Buy GW-501516 Powder

• PPARδ ligand. The thiazole, trifluoromethylphenyl, and phenoxyacetic acid distinguish it from SARMs and from REV-ERB agonists such as SR-9009.
• Documented identity. CAS 317318-70-0, PubChem CID 9803963, formula C21H18F3NO3S2, molar mass 453.5 g·mol−1.
• Carboxylic acid. The free acid is the assayed form. A salt, if supplied, must be declared because it changes formula weight.
• Weighable powder. Suitable for reference standards when the COA confirms HPLC purity.
• Laboratory-only handling. Intended for controlled chemical and in vitro work, not for dietary or performance use.

Specifications Of Buy GW-501516 Powder

Applications in research

Appropriate uses are non-clinical and institutionally approved:

• Analytical reference material for HPLC, LC-MS, and NMR identification of GW-501516.
• PPARδ reporter or binding assays where the protocol covers this compound.
• Forensic screening of products labeled cardarine, endurobol, or GW-501516.
• Impurity profiling of the thiazole phenoxyacetic acid scaffold.

Do not describe or imply oral use or any human performance protocol. Animal and discontinued clinical doses are not a use instruction.

Purity and testing

A defensible product claim rests on the batch certificate, not on a generic percentage.

• HPLC for chromatographic purity against a stated method.
• 1H NMR and 19F NMR for the phenoxyacetic acid, the thiazole methyl, and the CF3 group.
• Mass spectrometry for the molecular ion consistent with C21H18F3NO3S2.
• Confirmation that the sample is the free acid, not a salt or a different PPAR ligand.
• Residual solvent if the supplier states it.

Store the COA with the lot number. Do not use the deprecated CAS 813458-54-7 as the product number.

Disclaimer

For laboratory research use only. Not for human or veterinary consumption, not for diagnostic or therapeutic use, and not a food, drug, or dietary supplement. GW-501516 is not an authorized medicine. Development was stopped after long-term animal studies found tumors in multiple organs. It is prohibited by the World Anti-Doping Agency. Australia has scheduled it as an illegal substance. Legal status varies elsewhere. Buyers are responsible for confirming legality, licensing, import rules, and institutional approval before ordering or handling. Handle with standard laboratory PPE and dispose of waste under local hazardous-chemical rules. No statement on this page is a claim of safety, efficacy, or fitness for any human application.

Frequently asked questions

What is GW-501516?
GW-501516, also called cardarine and endurobol, is a selective PPARδ agonist, formula C21H18F3NO3S2. It is not a SARM.

Is this the same as SR-9009 or ostarine?
No. SR-9009 is a REV-ERB agonist. Ostarine is an androgen-receptor ligand. GW-501516 is CAS 317318-70-0 and acts at PPARδ.

Which CAS number applies?
CAS 317318-70-0. Do not use the deprecated number 813458-54-7.

What purity is supplied?
Only the figure on the lot COA. A page-level claim such as ≥98% by HPLC should match the method used for that batch.

How should it be stored?
Sealed, cool, dry, and protected from light, commonly at −20 °C for reference material. Record the lot number with the COA.

Can it be used in humans?
No. It is not an approved drug or supplement and is not sold for consumption. Anti-doping rules prohibit it. Animal carcinogenicity findings are a reason it was not developed as a medicine. Check local law before purchase.

What analytical methods confirm identity?
HPLC purity, 1H and 19F NMR, and mass spectrometry consistent with C21H18F3NO3S2. The COA should state free acid if that is the supplied form.