4-CL-PVP is 1-(4-chlorophenyl)-2-(pyrrolidin-1-yl)pentan-1-one. The content below is written for a research-chemical category page covering 4-CL-PVP materials. It does not include dosing, administration, or human-use claims. Each product requires its own lot-specific COA confirming identity, salt form, and assay.

Introduction

4-CL-PVP is 1-(4-chlorophenyl)-2-(pyrrolidin-1-yl)pentan-1-one. It is a synthetic cathinone with a chlorine atom at the 4-position of the phenyl ring and a pyrrolidine nitrogen. It is also known as 4-chloro-α-PVP. Products in this category are for laboratory research only where legally authorized. They are not medicines and are not sold for human consumption.

The free base is C₁₅H₂₀ClNO, 265.78 g·mol⁻¹, CAS 5881-77-6. The hydrochloride is C₁₅H₂₀ClNO·HCl, 302.2 g·mol⁻¹, CAS 5537-17-7. Products must state the free base or named salt on the label and COA. A category name does not confirm the identity or salt form of any individual lot.

Key Features & Benefits

• Defined 4-substituted pyrrolidinophenone. The 4-chloro and pyrrolidine groups are the structural markers that distinguish it from related cathinones.
• Documented identity: free-base CAS 5881-77-6, formula C₁₅H₂₀ClNO.
• Chlorine marker. Mass spectra show the chlorine isotope pair.
• Distinct from α-PVP. That compound lacks the chlorine.
• Suitable for controlled laboratory and forensic analytical work when legally authorized. Not for formulation or human administration.

Specifications Table

Applications in Research

Appropriate uses are non-clinical, institutionally approved, and legally authorized:

• Analytical reference material for HPLC, LC-MS, and NMR identification of 4-CL-PVP against a certified standard.
• Forensic differentiation from α-PVP and related cathinones.
• Comparison of free-base versus hydrochloride lots.
• In vitro monoamine transporter assays where the protocol specifically covers this compound.

Do not describe or imply oral, insufflation, or any other human route of administration. Do not treat any labeled milligram quantity as a dose.

Purity & Testing

A defensible product claim rests on the batch certificate of analysis for the specific form.

• HPLC for chromatographic purity, with retention that separates 4-CL-PVP from related cathinones.
• ¹H NMR confirming the 4-chloro aromatic pattern and the pyrrolidine.
• Mass spectrometry consistent with the free-base molecular ion of C₁₅H₂₀ClNO, including the chlorine isotope pair.
• Explicit statement of free base or named salt.
• Residual solvent and related-substance limits if stated by the supplier.

Store the COA with the lot number. Do not use an α-PVP CAS number for a 4-CL-PVP lot.

Disclaimer

For laboratory research use only, where legally authorized. Not for human or veterinary consumption, not for diagnostic or therapeutic use, and not a food, drug, or cosmetic. 4-CL-PVP is a Class B substance in the United Kingdom, is restricted under the German NpSG, and is a Schedule I substance in the United States. Related cathinones are controlled in many jurisdictions, and analogue rules may apply. Unauthorized possession, manufacture, distribution, or importation can be a criminal offense. Buyers are solely responsible for confirming legality, licensing, import rules, and institutional approval before ordering or handling any specific product. Handle under applicable controlled-substance and hazardous-chemical rules and dispose of waste according to local regulations. No statement on this page is a claim of safety, efficacy, or fitness for any human application. The category name does not replace lot-specific identity and purity data on the COA.

Frequently Asked Questions

What is 4-CL-PVP?
It is 1-(4-chlorophenyl)-2-(pyrrolidin-1-yl)pentan-1-one. The free base is C₁₅H₂₀ClNO, 265.78 g·mol⁻¹.

Is this the same as α-PVP?
No. α-PVP lacks the chlorine. 4-CL-PVP has the chlorine at the 4-position, CAS 5881-77-6. Mass spectra and NMR distinguish them by the chlorine isotope pair.

Which CAS number applies?
Free base CAS 5881-77-6. Hydrochloride CAS 5537-17-7. Confirm identity and salt form on the COA.

What purity is supplied?
Only the value stated on the specific lot COA, together with the analytical method. The method should resolve 4-CL-PVP from related compounds.

How should it be stored?
Sealed, cool, dry, and protected from light under the rules that apply. Keep the lot number with the COA.

Can it be used in humans?
No. It is not an approved medicine and is not sold for consumption. In the United Kingdom it is Class B. Check local law before purchase or handling.

What analytical methods confirm identity?
HPLC with related-compound resolution, NMR for the 4-chloro pattern, and mass spectrometry consistent with C₁₅H₂₀ClNO (including the chlorine isotope pair). The COA should state free base or salt.