Etizolam is 4-(2-chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine. The content below is written for a research-chemical category page covering etizolam materials. It does not include dosing, administration, or human-use claims. Each product requires its own lot-specific COA confirming identity and assay.

Introduction

Etizolam is 4-(2-chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine. It is a thienotriazolodiazepine. A chlorine atom sits at the ortho position of the C4-phenyl ring, an ethyl group sits at the 2-position of the thiophene ring, and a methyl group sits on the triazole. It is the 2′-chloro analogue of deschloroetizolam, which lacks that chlorine.

It is not an approved medicine in most jurisdictions. The free base is C₁₇H₁₅ClN₄S, 342.85 g·mol⁻¹, CAS 40054-69-1. Products in this category (powder, pellets, or other forms) must state the form on the label and COA. A category name does not confirm the identity of any individual lot.

Key Features & Benefits

• Defined thienotriazolodiazepine. The 2′-chloro substitution is the structural marker that distinguishes it from deschloroetizolam.
• Documented identity: CAS 40054-69-1, formula C₁₇H₁₅ClN₄S.
• Chlorine marker. Mass spectra show the characteristic chlorine isotope pair.
• Distinct from deschloroetizolam. That compound lacks the phenyl chlorine (free-base CAS 40054-73-7, C₁₇H₁₆N₄S, 308.40 g·mol⁻¹).
• Suitable for controlled laboratory and forensic analytical work when legally authorized. Not for formulation or human administration.

Specifications Table

Applications in Research

Appropriate uses are non-clinical, institutionally approved, and legally authorized:

• Analytical reference material for HPLC, LC-MS, and NMR identification of etizolam against a certified standard.
• Forensic differentiation from deschloroetizolam and other thienodiazepines.
• In vitro GABA-A receptor assays where the protocol specifically covers this compound.

Do not describe or imply oral, insufflation, injection, or any other human route of administration. Do not treat any labeled milligram quantity as a dose.

Purity & Testing

A defensible product claim rests on the batch certificate of analysis for the specific form.

• HPLC for chromatographic purity, with retention that separates etizolam from deschloroetizolam.
• ¹H NMR confirming the 2′-chloro phenyl pattern, the ethyl, and the methyl.
• Mass spectrometry consistent with the free-base molecular ion of C₁₇H₁₅ClN₄S, including the chlorine isotope pair.
• Residual solvent and related-substance limits if stated by the supplier.

Store the COA with the lot number. Do not use a deschloroetizolam CAS number for an etizolam lot.

Disclaimer

For laboratory research use only, where legally authorized. Not for human or veterinary consumption, not for diagnostic or therapeutic use, and not a food, drug, or cosmetic. Etizolam is a Class C substance in the United Kingdom, Anlage III in Germany, and Schedule IV under the 1971 Convention on Psychotropic Substances. Unauthorized possession, manufacture, distribution, or importation can be a criminal offense. Buyers are solely responsible for confirming legality, licensing, import rules, and institutional approval before ordering or handling any specific product. Handle under applicable controlled-substance and hazardous-chemical rules and dispose of waste according to local regulations. No statement on this page is a claim of safety, efficacy, or fitness for any human application. The category name does not replace lot-specific identity and purity data on the COA.

Frequently Asked Questions

What is etizolam?
It is 4-(2-chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine. The free base is C₁₇H₁₅ClN₄S, 342.85 g·mol⁻¹.

Is this the same as deschloroetizolam?
No. Deschloroetizolam lacks the phenyl chlorine (CAS 40054-73-7). Etizolam has a 2′-chloro, CAS 40054-69-1. Mass spectra distinguish them by the chlorine isotope pair.

Which CAS number applies?
CAS 40054-69-1. Confirm identity and form on the COA.

What purity is supplied?
Only the value stated on the specific lot COA, together with the analytical method. The method should resolve etizolam from related compounds.

How should it be stored?
Sealed, cool, dry, and protected from light under the rules that apply. Keep the lot number with the COA.

Can it be used in humans?
No. It is not sold for consumption. In the United Kingdom it is Class C. Check local law before purchase or handling.

What analytical methods confirm identity?
HPLC with related-compound resolution, NMR for the 2′-chloro pattern, and mass spectrometry consistent with C₁₇H₁₅ClN₄S (including the chlorine isotope pair). Absence of the chlorine isotope pair means the sample is not etizolam.