3-Me-PCPy is 1-[1-(3-methylphenyl)cyclohexyl]pyrrolidine. The content below is written for a research-chemical category page covering 3-Me-PCPy materials. It does not include dosing, administration, or human-use claims. Each product requires its own lot-specific COA confirming identity, salt form, stereochemistry, and assay.

Introduction

3-Me-PCPy is 1-[1-(3-methylphenyl)cyclohexyl]pyrrolidine. It is a methyl-substituted arylcyclohexylamine related to rolicyclidine (PCPy). A methyl group sits at the meta (3-) position of the phenyl ring, and a pyrrolidine ring is attached at the same carbon as the phenyl on the cyclohexane. It is the 3-methyl analogue of PCPy, which has no ring methyl, and it is structurally related to 3-Me-PCP, which has a piperidine instead of a pyrrolidine. The cyclohexyl carbon bearing the aryl and pyrrolidine is a stereocenter.

It is not an approved medicine. The free base is C₁₇H₂₅N, 243.39 g·mol⁻¹, CAS 1622348-63-3. The hydrochloride is C₁₇H₂₆ClN, 279.9 g·mol⁻¹, CAS 1622348-68-8. Products in this category (powder, crystal, or other forms) must state free base versus hydrochloride and racemate versus named enantiomer on the label and COA. A category name does not confirm the salt or stereochemistry of any individual lot.

Key Features & Benefits

• Defined meta-methyl PCPy analogue. The 3-methyl substitution and the pyrrolidine ring are the structural markers that distinguish it from the parent and from piperidine analogues.
• Documented identity: free-base CAS 1622348-63-3; hydrochloride CAS 1622348-68-8.
• Methyl marker. NMR confirms the aromatic methyl singlet.
• Distinct from PCPy and 3-Me-PCP. PCPy lacks the methyl; 3-Me-PCP has a six-membered piperidine ring and a higher mass.
• Suitable for controlled laboratory and forensic analytical work when legally authorized. Not for formulation or human administration.

Specifications Table

Applications in Research

Appropriate uses are non-clinical, institutionally approved, and legally authorized:

• Analytical reference material for HPLC, LC-MS, and NMR identification of 3-Me-PCPy against a certified standard.
• Forensic differentiation from PCPy, 3-Me-PCP, and other arylcyclohexylamine analogues.
• Comparison of free-base versus hydrochloride lots and of racemic versus enantiomerically enriched material.
• In vitro NMDA-receptor or monoamine-transporter assays where the protocol specifically covers this compound.

Do not describe or imply oral, insufflation, injection, or any other human route of administration. Do not treat any labeled milligram quantity as a dose.

Purity & Testing

A defensible product claim rests on the batch certificate of analysis for the specific form.

• HPLC for chromatographic purity, with retention that separates 3-Me-PCPy from PCPy and from 3-Me-PCP.
• ¹H NMR confirming the meta-methyl aromatic pattern and the pyrrolidine signals. A piperidine pattern indicates 3-Me-PCP; absence of the aromatic methyl indicates PCPy.
• Mass spectrometry consistent with the free-base molecular ion of C₁₇H₂₅N.
• Explicit statement of free base or named salt and of stereochemistry (racemate or named enantiomer).
• Residual solvent and related-substance limits if stated by the supplier.

Store the COA with the lot number. Do not use a PCPy or 3-Me-PCP CAS number for a 3-Me-PCPy lot.

Disclaimer

For laboratory research use only, where legally authorized. Not for human or veterinary consumption, not for diagnostic or therapeutic use, and not a food, drug, or cosmetic. 3-Me-PCPy is a Class B substance in the United Kingdom, is restricted under the German NpSG, and is Schedule I in Canada. Rolicyclidine is a controlled substance in many jurisdictions, and analogue rules may apply. Unauthorized possession, manufacture, distribution, or importation can be a criminal offense. Buyers are solely responsible for confirming legality, licensing, import rules, and institutional approval before ordering or handling any specific product. Handle under applicable controlled-substance and hazardous-chemical rules and dispose of waste according to local regulations. No statement on this page is a claim of safety, efficacy, or fitness for any human application. The category name does not replace lot-specific identity and purity data on the COA.

Frequently Asked Questions

What is 3-Me-PCPy?
It is 1-[1-(3-methylphenyl)cyclohexyl]pyrrolidine. The free base is C₁₇H₂₅N, 243.39 g·mol⁻¹.

Is the product the free base?
Not unless the COA says so. The hydrochloride is CAS 1622348-68-8 and weighs 279.9 g·mol⁻¹. The COA must state the form.

Is this the same as PCPy or 3-Me-PCP?
No. PCPy has no ring methyl. 3-Me-PCP has a piperidine ring instead of pyrrolidine (free-base C₁₈H₂₇N, 257.41 g·mol⁻¹). 3-Me-PCPy is the meta-methyl pyrrolidine compound, free-base CAS 1622348-63-3.

Which CAS number applies?
CAS 1622348-63-3 for the free base. CAS 1622348-68-8 for the hydrochloride. Use the number that matches the form on the COA and confirm stereochemistry.

What purity is supplied?
Only the value stated on the specific lot COA, together with the analytical method. The method should resolve 1-[1-(3-methylphenyl)cyclohexyl]pyrrolidine from related analogues.

How should it be stored?
Sealed, cool, dry, and protected from light under the rules that apply. Keep the lot number with the COA.

Can it be used in humans?
No. It is not an approved medicine and is not sold for consumption. In the United Kingdom it is Class B. Check local law before purchase or handling.

What analytical methods confirm identity?
HPLC with analogue resolution, NMR for the meta-methyl and pyrrolidine pattern, and mass spectrometry consistent with C₁₇H₂₅N. A piperidine pattern means the sample is not 3-Me-PCPy. Missing aromatic methyl means it is not 3-Me-PCPy. The COA should state free base or salt and stereochemistry.