2F-Ketamine (2-FDCK) is 2-(2-fluorophenyl)-2-(methylamino)cyclohexan-1-one. The content below is written for a research-chemical category page covering 2F-Ketamine materials. It does not include dosing, administration, or human-use claims. Each product requires its own lot-specific COA confirming identity, salt form, stereochemistry, and assay.

Introduction

2F-Ketamine (2-FDCK) is 2-(2-fluorophenyl)-2-(methylamino)cyclohexan-1-one. It is a fluorinated arylcyclohexylamine related to ketamine. A fluorine atom sits at the ortho (2-) position of the phenyl ring, a methylamino group sits at C2 of the cyclohexanone, and a ketone sits at C1. It is the deschloro, 2-fluoro analogue of ketamine, which has a chlorine at the ortho position instead of fluorine. The C2 carbon is a stereocenter.

It is not an approved medicine. The free base is C₁₃H₁₆FNO, 221.27 g·mol⁻¹, CAS 111982-50-4. The hydrochloride is C₁₃H₁₇ClFNO, 257.73 g·mol⁻¹, CAS 111982-49-1. Products in this category (powder, crystal, pellets, or other forms) must state free base versus hydrochloride and racemate versus named enantiomer on the label and COA. A category name does not confirm the salt or stereochemistry of any individual lot.

Key Features & Benefits

• Defined 2-fluoro arylcyclohexylamine ketone. The 2-fluoro substitution and the cyclohexanone are the structural markers that distinguish it from ketamine and from other ring-substituted analogues.
• Documented identity: free-base CAS 111982-50-4; hydrochloride CAS 111982-49-1.
• Fluorine marker. ¹⁹F NMR can confirm the ortho-fluoro pattern.
• Distinct from ketamine. That compound has an ortho-chloro substituent (free-base CAS 6740-88-1, C₁₃H₁₆ClNO, 237.73 g·mol⁻¹).
• Suitable for controlled laboratory and forensic analytical work when legally authorized. Not for formulation or human administration.

Specifications Table

Applications in Research

Appropriate uses are non-clinical, institutionally approved, and legally authorized:

• Analytical reference material for HPLC, LC-MS, and NMR identification of 2-FDCK against a certified standard.
• Forensic differentiation from ketamine, DCK, and other arylcyclohexylamine analogues.
• Comparison of free-base versus hydrochloride lots and of racemic versus enantiomerically enriched material.
• In vitro NMDA-receptor assays where the protocol specifically covers this compound.

Do not describe or imply oral, insufflation, injection, or any other human route of administration. Do not treat any labeled milligram quantity as a dose.

Purity & Testing

A defensible product claim rests on the batch certificate of analysis for the specific form.

• HPLC for chromatographic purity, with retention that separates 2-FDCK from ketamine and from related fluoro or chloro analogues.
• ¹H NMR and/or ¹⁹F NMR confirming the ortho-fluoro aromatic pattern, the N-methyl, and the cyclohexanone. A chloro pattern indicates ketamine; absence of fluorine indicates DCK.
• Mass spectrometry consistent with the free-base molecular ion of C₁₃H₁₆FNO.
• Explicit statement of free base or named salt and of stereochemistry (racemate or named enantiomer).
• Residual solvent and related-substance limits if stated by the supplier.

Store the COA with the lot number. Do not use a ketamine or DCK CAS number for a 2-FDCK lot.

Disclaimer

For laboratory research use only, where legally authorized. Not for human or veterinary consumption, not for diagnostic or therapeutic use, and not a food, drug, or cosmetic. 2-FDCK is a Class B substance in the United Kingdom, Anlage II in Germany, and Schedule I in Canada. Ketamine is a controlled substance in many jurisdictions, and analogue rules may apply. Unauthorized possession, manufacture, distribution, or importation can be a criminal offense. Buyers are solely responsible for confirming legality, licensing, import rules, and institutional approval before ordering or handling any specific product. Handle under applicable controlled-substance and hazardous-chemical rules and dispose of waste according to local regulations. No statement on this page is a claim of safety, efficacy, or fitness for any human application. The category name does not replace lot-specific identity and purity data on the COA.

Frequently Asked Questions

What is 2F-Ketamine (2-FDCK)?
It is 2-(2-fluorophenyl)-2-(methylamino)cyclohexan-1-one. The free base is C₁₃H₁₆FNO, 221.27 g·mol⁻¹.

Is the product the free base?
Not unless the COA says so. The hydrochloride is CAS 111982-49-1 and weighs 257.73 g·mol⁻¹. The COA must state the form.

Is this the same as ketamine or DCK?
No. Ketamine has an ortho-chloro substituent (free-base CAS 6740-88-1). DCK has no halogen on the phenyl ring. 2-FDCK is the ortho-fluoro compound, free-base CAS 111982-50-4.

Which CAS number applies?
CAS 111982-50-4 for the free base. CAS 111982-49-1 for the hydrochloride. Use the number that matches the form on the COA and confirm stereochemistry.

What purity is supplied?
Only the value stated on the specific lot COA, together with the analytical method. The method should resolve 2-FDCK from related analogues.

How should it be stored?
Sealed, cool, dry, and protected from light under the rules that apply. Keep the lot number with the COA.

Can it be used in humans?
No. It is not an approved medicine and is not sold for consumption. In the United Kingdom it is Class B. Check local law before purchase or handling.

What analytical methods confirm identity?
HPLC with analogue resolution, NMR (including ¹⁹F) for the ortho-fluoro, N-methyl, and cyclohexanone pattern, and mass spectrometry consistent with C₁₃H₁₆FNO. A chloro pattern means the sample is not 2-FDCK. Missing fluorine means it is not 2-FDCK. The COA should state free base or salt and stereochemistry.